Liverpool started the ball rolling with a convincing 4-1 win at home to promoted Norwich and City responded a day later with an even more emphatic 5-0 victory at West Ham United.
Whatever happens, there will be no shortage of drama between now and May 12.
Liverpool's dream run was demolished in the most unlikely fashion by strugglers Watford on Saturday in what must be considered the most extraordinary reverse of the entire Premier League season. On the evening when the European champions were expected to complete the best sequence in the history of English football's top-flight with a 19th straight league victory, they were instead hammered 3-0 by the team lying one from bottom. Images from the EPL matches played on Saturday.
Gabriel Jesus came off the bench to secure Manchester City a 1-0 English Premier League victory at Leicester City after yet another penalty miss by Pep Guardiola's side on Saturday. Chelsea's Olivier Giroud and Marcos Alonso returned to the starting lineup to stunning effect by grabbing a goal apiece in a crucial 2-1 home win over Tottenham Hotspur in the battle between the London rivals for fourth place.
Talking points from this weekend's Premier League action as top two Manchester City and Liverpool both won with City remaining a point clear with two games remaining.
Winter returned to Anfield on Friday but while the temperature dropped, the standards of Juergen Klopp's side certainly did not as Sadio Mane and Mohamed Salah both struck twice in a 5-0 thrashing of relegated Huddersfield Town.
"Liverpool FC are delighted to announce that they have agreed personal terms with Danny Ings and, subject to a medical, the striker will join the club on July 1 after his contract with Burnley has expired," the club said on their website (www.liverpoolfc.com).
The draw pushed Chelsea up a place into fourth spot in the Premier League, level on points with third-placed Spurs and one point ahead of Arsenal, both of whom have a played a game less.
Such is the level of consistency of Manchester City (nine straight wins) and Liverpool (five straight victories), that it can be easy to lose sight of just how good this title race is.
Burnley's seemingly doomed attempt to avoid relegation from the Premier League.
Rewind five years and Liverpool hosted Chelsea with three games remaining, knowing victory would have left them six points clear and a first league title since 1990 almost secure.
Liverpool a dramatic 2-1 victory over Leicester City at Anfield, thus maintaining the league leaders' 100 per cent start
Chelsea offered a chink of light to Manchester City in the Premier League title race after a stormy 1-1 home draw with Burnley on Saturday that gave more ammunition to their outspoken manager Jose Mourinho.
A preview of the line-up action in the English Premier League
Two goals each for Roberto Firmino and Sadio Mane helped Liverpool to keep in touch with Premier League leaders Manchester City with a 4-2 win over lowly Burnley at Anfield on Sunday.
The following are talking points from the weekend's Premier League action:
News of all that's transpired on and off the football field.
English Premier League leaders Liverpool will need to maintain their excellent recent record against Everton in Sunday's Merseyside derby if they are to hold their advantage over second-placed Manchester City.
Tottenham Hotspur stormed back from 2-0 down to beat Burnley 4-2 in their FA Cup third-round replay on Wednesday despite resting their top striker in the once-fabled competition.
IMAGES from the English Premier League matches played on Tuesday
Here are five talking points from the weekend's action:
Here are five talking points from the weekend's action:
IMAGES from Saturday's English Premier League matches.
Manchester City begin a crucial week in the Premier League title race when they host Arsenal at the Etihad on Sunday.
Images from the English Premier League matches played on Saturday.
News of all that transpired on and off the football field
A last-minute own goal gave Liverpool a 2-1 win over Tottenham Hotspur to keep them top of the Premier League but Manchester City stayed two points behind having won at Fulham. Huddersfield Town were relegated after their defeat by Crystal Palace.
Arsenal coach Arteta has said that Granit Xhaka will stay at the London club while United have new headaches with injuries to Paul Pogba and Scott McTominay.
Leicester City's traumatic week ended with a 1-0 win at Cardiff City although the result was never the chief concern on a day when the tributes flowed for the Midlands club's late owner Vichai Srivaddhanaprabha who died in a helicopter crash.
McTominay injury takes gloss of vibrant United display
United down Newcastle after Saints stun Chelsea on a dramatic night in the English Premier League.
Making the most of a rare start for Sarri's side, Loftus-Cheek inspired Chelsea to a 3-1 Europa League win over the Belarus champions at Stamford Bridge on Thursday.
Raheem Sterling scored a second-half hat-trick as leaders Manchester City beat Watford 3-1 on Saturday while Liverpool kept the gap at one point by overcoming Burnley 4-2 on Sunday.
A preview of the line-up action in the English Premier League
Tottenham Hotspur routed Bournemouth 5-0 as they leapfrogged City into second place in the league, six points behind leaders Liverpool who thrashed Newcastle United 4-0.
IMAGES from the EPL matches played on Wednesday
News of all that's transpired on and off the football field
Under-fire Manchester United boss Jose Mourinho has been priced odds-on to be the first Premier League manager to leave his job this season.
The ball was in play in Burnley's 2-1 win for just 42 minutes and two seconds out of the regulation 90 minutes.